BPIFA3

BPI fold containing family A, member 3 is a protein that in humans is encoded by the BPIFA3 gene.[5] The gene is also known as SPLUNC3 and C20orf71 in humans and the orthologous gene in mice is 1700058C13Rik.[5]

BPIFA3
Identifiers
AliasesBPIFA3, C20orf71, SPLUNC3, BPI fold containing family A member 3
External IDsMGI: 1920638 HomoloGene: 52268 GeneCards: BPIFA3
Orthologs
SpeciesHumanMouse
Entrez

128861

73388

Ensembl

ENSG00000131059

ENSMUSG00000027482

UniProt

Q9BQP9

Q9D9J8

RefSeq (mRNA)

NM_001042439
NM_178466

NM_001291079
NM_028528

RefSeq (protein)

NP_001035904
NP_848561

NP_001278008
NP_082804

Location (UCSC)Chr 20: 33.22 – 33.23 MbChr 2: 153.97 – 153.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of BPIFA3 function. A conditional knockout mouse line, called 1700058C13Riktm1a(KOMP)Wtsi[10][11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[12][13][14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty three tests were carried out on mutant mice, but no significant abnormalities were observed.[8]

References
  1. GRCh38: Ensembl release 89: ENSG00000131059 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027482 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "BPI fold containing family A, member 3". Retrieved 2011-12-07.
  6. "Salmonella infection data for 1700058C13Rik". Wellcome Trust Sanger Institute.
  7. "Citrobacter infection data for 1700058C13Rik". Wellcome Trust Sanger Institute.
  8. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  9. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  10. "International Knockout Mouse Consortium".
  11. "Mouse Genome Informatics".
  12. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, et al. (June 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  13. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–263. doi:10.1038/474262a. PMID 21677718.
  14. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  15. van der Weyden L, White JK, Adams DJ, Logan DW (June 2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading
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