EIF2AK4

EIF2AK4
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	1UKX, 4OTN
Pengidentifikasi
Alias	EIF2AK4, GCN2, PVOD2, eukaryotic translation initiation factor 2 alpha kinase 4
ID eksternal	OMIM: 609280 MGI: 1353427 HomoloGene: 40891 GeneCards: EIF2AK4
Lokasi gen (Manusia)
Kr.	Kromosom 15 (manusia)[1]
Akhir	40,035,591 bp[1]
Lokasi gen (Tikus)
Kr.	Kromosom 2 (tikus)[2]
Akhir	118,305,715 bp[2]
Ontologi gen
Fungsi molekuler	• transferase activity; • nucleotide binding; • protein kinase activity; • tRNA binding; • kinase activity; • protein serine/threonine kinase activity; • RNA binding; • ATP binding; • eukaryotic translation initiation factor 2alpha kinase activity;
Komponen seluler	• sitoplasma; • polysome; • cytosolic ribosome;
Proses biologis	• positive regulation of translational initiation in response to starvation; • adaptive immune response; • negative regulation of neuron differentiation; • positive regulation of long-term synaptic potentiation; • positive regulation of adaptive immune response; • negative regulation of translational initiation in response to stress; • negative regulation of translational initiation; • Fosforilasi; • immune system process; • cellular response to UV; • cellular response to amino acid starvation; • negative regulation of CREB transcription factor activity; • regulation of feeding behavior; • belajar; • perkembangan sistem saraf; • viral translation; • neuron projection extension; • protein phosphorylation; • cellular response to cold; • long-term memory; • defense response to virus; • cellular response to leucine starvation; • eiF2alpha phosphorylation in response to endoplasmic reticulum stress; • induction by virus of host autophagy; • protein autophosphorylation; • Siklus sel; • negative regulation by host of viral genome replication; • GO:0022415 viral process; • regulation of translation; • regulation of translational initiation; • positive regulation of defense response to virus by host; • T cell activation involved in immune response; • DNA damage checkpoint signaling; • regulation of translational initiation by eIF2 alpha phosphorylation;
	Sumber:Amigo / QuickGO
Ortolog
	440275
	27103
	ENSG00000128829
	ENSMUSG00000005102
	Q9P2K8
	Q9QZ05
	NM_001013703
	NM_001177806; NM_013719; NM_001355383
	NP_001013725
	NP_001171277; NP_038747; NP_001342312
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Eukaryotic translation initiation factor 2-alpha kinase 4 adalah enzim yang disandikan oleh gen EIF2AK4 dalam tubuh manusia.[5][6]

Dalam kedokteran

Mutasi pada gen ini dapat memicu hipertensi paru.[7]

Referensi

GRCh38: Ensembl release 89: ENSG00000128829 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000005102 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Berlanga JJ, Santoyo J, De Haro C (Nov 1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase". Eur J Biochem. 265 (2): 754–62. doi:10.1046/j.1432-1327.1999.00780.x. PMID 10504407.
"Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4".
Eyries M, Montani D, Girerd B et al. EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension, Nat Genet, 2014;46:65–69

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128829 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005102 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10504407-5] Berlanga JJ, Santoyo J, De Haro C (Nov 1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase". Eur J Biochem. 265 (2): 754–62. doi:10.1046/j.1432-1327.1999.00780.x. PMID 10504407.

[entrez-6] "Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4".

[Eyries_2014-7] Eyries M, Montani D, Girerd B et al. EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension, Nat Genet, 2014;46:65–69