Endopeptidase C30
Endopeptidase C30 dalam berbagai coronavirus, sering disebut "3C-like proteinase", merupakan keluarga enzim yang ditemukan dalam poliprotein Coronavirus dan memotong polyprotein di dua situs pembelahan diri. Endopeptidase C30 adalah sisteina protease di bawah klan PA, klasifikasi MEROPS C30.
| Peptidase C30, Coronavirus endopeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikasi | |||||||||
| Simbol | Peptidase_C30 | ||||||||
| Pfam | PF05409 | ||||||||
| InterPro | IPR008740 | ||||||||
| PROSITE | PS51442 | ||||||||
| MEROPS | C30 | ||||||||
| SCOP | d1q2wb1 | ||||||||
| SUPERFAMILY | d1q2wb1 | ||||||||
| |||||||||
| SARS coronavirus main proteinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Oktamer proteinase utama SARS. | |||||||||
| Pengidentifikasi | |||||||||
| Nomor EC | 3.4.22.69 | ||||||||
| Basis data | |||||||||
| IntEnz | tinjauan IntEnz | ||||||||
| BRENDA | entri BRENDA | ||||||||
| ExPASy | tinjauan NiceZyme | ||||||||
| KEGG | entri KEGG | ||||||||
| MetaCyc | jalur metabolik | ||||||||
| PRIAM | profil | ||||||||
| Struktur PDB | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Komisi Enzim mencatat keluarga ini sebagai "proteinase utama SARS coronavirus" (Nomor EC: 3.4.22.69). Nama umum "3C" mengacu pada Enterovirus protease 3C.
Fungsi
Enzim ini mengkatalisasi reaksi kimia:[1][2][3]
TSAVLQ-SGFRK-NH2 dan SGVTFQ-!GKFKK adalah dua peptida yang sesuai dengan dua situs pembelahan diri dari proteinase seperti SARS 3C
Enzim ini penting dalam pemrosesan polyprotein SARS coronavirus.
Referensi
- Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS (July 2007). "Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus". Biochemistry. 46 (30): 8744–52. doi:10.1021/bi0621415. PMID 17605471.
- Fan K, Wei P, Feng Q, Chen S, Huang C, Ma L, Lai B, Pei J, Liu Y, Chen J, Lai L (January 2004). "Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase". The Journal of Biological Chemistry. 279 (3): 1637–42. doi:10.1074/jbc.m310875200. PMID 14561748.
- Akaji K, Konno H, Onozuka M, Makino A, Saito H, Nosaka K (November 2008). "Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant". Bioorganic & Medicinal Chemistry. 16 (21): 9400–8. doi:10.1016/j.bmc.2008.09.057. PMID 18845442.
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