GADD45B

GADD45B
Pengidentifikasi
Alias	GADD45B, GADD45BETA, MYD118, growth arrest and DNA damage inducible beta
ID eksternal	OMIM: 604948 MGI: 107776 HomoloGene: 7433 GeneCards: GADD45B
Lokasi gen (Tikus)
Kr.	Kromosom 10 (tikus)[1]
Akhir	80,768,038 bp[1]
Pola ekspresi RNA
	; ; ; ;
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• GO:0001948 Ikatan protein plasma;
Komponen seluler	• sitoplasma; • Inti sel;
Proses biologis	• multicellular organism development; • positive regulation of apoptotic process; • positive regulation of p38MAPK cascade; • response to stress; • Diferensiasi sel; • positive regulation of JNK cascade; • negative regulation of protein kinase activity; • Apoptosis; • regulation of cell cycle;
	Sumber:Amigo / QuickGO
Ortolog
	4616
	17873
	ENSG00000099860
	ENSMUSG00000015312
	O75293
	P22339
	NM_015675
	NM_008655
	NP_056490
	NP_032681
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

GADD45B (bahasa Inggris: Growth arrest and DNA-damage-inducible beta, GADD-45B) adalah berkas genetik yang terletak pada kromosom 19 lokasi 19p13.3.[4]

Ekspresi genetik GADD45B diidentifikasi pada neuron hipokampus. Pada model tikus, tanpa berkas GADD45B menyebabkan difisiensi proliferasi spesifik dari sel progenitor neuron dan pertumbuhan dendrit neuron baru. Berkas GADD45B dibutuhkan pula pada proses demetilasi DNA yang dipicu oleh promoter inti tertentu dan transkripsi gen terkait pada lintasan metabolisme neurogenesis, termasuk berkas genetik faktor neurotrofik dan faktor pertumbuhan fibroblas.[5]

Rujukan

GRCm38: Ensembl release 89: ENSMUSG00000015312 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
(Inggris) "GADD45B growth arrest and DNA-damage-inducible, beta [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-10-28.
(Inggris) "Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis". Institute for Cell Engineering, Johns Hopkins University School of Medicine; Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, Flavell RA, Lu B, Ming GL, Song H. Diakses tanggal 2010-10-28.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000015312 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] (Inggris) "GADD45B growth arrest and DNA-damage-inducible, beta [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-10-28.

[5] (Inggris) "Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis". Institute for Cell Engineering, Johns Hopkins University School of Medicine; Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, Flavell RA, Lu B, Ming GL, Song H. Diakses tanggal 2010-10-28.