Reseptor histamin

Reseptor histamin adalah anggota reseptor terhubung-protein G dengan ligan alaminya yaitu histamin.[1]

Klasifikasi
  • Reseptor H1
  • Reseptor H2
  • Reseptor H3
  • Reseptor H4

Perbandingan
Reseptor histamin
ReseptorMekanismeFungsiAntagonis
H1 Gq
  • kontraksi ileum
  • modulasi siklus sirkadian
  • gatal
  • vasodilatasi sistemik
  • bronkokonstriksi (asma terinduksi alergi)
H2 Gs
↑ cAMP2+
  • mempercepat ritme sinus
  • stimulasi sekresi asam lambung
  • relaksasi otot polos
  • menghambat sintesis antibodi, proliferasi sel T, dan produksi sitokin
H3 Gi
  • H3-receptor antagonists
    • ABT-239
    • Ciproxifan
    • Clobenpropit
    • Thioperamide
H4 Gi
  • memediasi kemotaksi sel mast.[2]
  • H4-receptor antagonists
    • Thioperamide
    • JNJ 7777120

Referensi
  1. Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL (1997). "International Union of Pharmacology. XIII. Classification of histamine receptors". Pharmacol. Rev. 49 (3): 253–78. PMID 9311023.
  2. Hofstra CL, Desai PJ, Thurmond RL, Fung-Leung WP (2003). "Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells". J. Pharmacol. Exp. Ther. 305 (3): 1212–21. doi:10.1124/jpet.102.046581. PMID 12626656.
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