Mouna Raagam 2

• Raveena Daha[5][6][7] as Shakthi (Sathya) – Karthik and Mallika's daughter and Varun's wife
• Shilpa[8] as Shruthi - Raghav and Kadhambari's daughter; Tharun's wife
• Salmanul Faris as Varun Manoharan - Manohar and Kasthuri's elder son; Shakthi's husband[9]
• Rahul Ramachandran as Tharun Manoharan – Manoharan and Kasthuri's younger son; Varun's brother; Shruthi's husband.
• Rajeev Parameshwar as Karthik Krishna – Playback singer; Parvati's younger son; Murali's brother; Mallika and Kaadhambari's husband; Shakthi and Shruti's father.[10]
• Chippy Ranjith as Mallika- Natural singer, Palani's sister. Karthik's first wife and Shakthi's mother

• Anusree Chembakaserry as Kaadhambari- Vishwanathan and Rukmani's elder daughter. Karthik's second wife and Shruthi's mother
• A. Revathy as Parvathi Krishna – Murali's and Karthik's mother; Shakthi and Shruti's grandmother.
• Uday Mahesh / Krishna Kumar Menon as Manoharan – Karthik's best friend; Sheela's brother; Kasthuri's husband; Varun and Tharun's father.
• Divya Binu as Sheela – Manoharan's sister; Varun and Tharun's aunt; Kasthuri's sister-in-law.
• Manjula / Remya Sudha as Kasthuri Manoharan – Manoharan's wife; Varun and Tharun's mother.
• Anjali Devi as Rukmani Vishwanathan – Vishwanathan's wife; Kadhambari and Maya's mother; Shruthi's grandmother.
• Kailas Nath as Sugumar - Shakthi's uncle.
• Supergood Kannan as Pazhaniswamy aka Pazhani – Mallika's brother; Swarna's husband; Nila's father; Shakthi's uncle.
• Seema G. Nair as Swarna Pazhaniswamy – Pazhani's wife; Nila's mother; Shakthi's aunt.
• Anand Babu as Vishwanathan – Rukmani's husband; Kaadhambari and Maya's father; Shruthi's grandfather
• Reshma Nandhu as Shalini

• Suriya as himself
• Shiva as himself
• Priya Anand as herself
• Sivaangi Krishnakumar as herself
• Rashmika Mandanna as herself
• Manju Warrier as herself
• Parineeti Chopra as herself
• Tara Alisha Berry as herself
• Devayani as herself
• Samantha Ruth Prabhu as herself
• Khushboo as herself
• Alia Bhatt as herself
• Radhika Pandit as herself
• Isha Talwar as herself
• Kriti Kharbanda as herself
• Priyanka Arul Mohan as herself
• Kriti Sanon as herself
• Erica Fernandes as herself
• Sathyaraj as himself
• Nupur Sanon as herself
• Shraddha Kapoor as herself
• Rakul Preet Singh as herself
• Shanvi Srivastava as herself
• Hansika Motwani as herself
• Sayyeshaa Saigal as herself
• Shalini Pandey as herself
• Shivarajkumar as himself
• Darshan Thoogudeepa as himself
• Puneeth Rajkumar as himself
• Yash as himself
• Ganesh as himself
• Sudeep as himself
• Jiiva as himself
• Udhayanidhi Stalin as himself
• Silambarasan as himself
• Cheran as himself
• Saravanan Arul as himself
• Nivin Pauly as himself
• Dhanush as himself
• Ranbir Kapoor as himself
• Ranveer Singh as himself
• Varun Dhawan as himself
• Sivakarthikeyan as himself
• Prabhas as himself
• Sadhu Kokila as himself
• Vadivelu as himself
• Chikkanna as himself
• Mallika Singh as herself

The first promo was unveiled on 11 January 2021, featuring the cast, the second promo was unveiled on 28 January 2021,[11] by revealing the release date.