Receptor D₂ de dopamina

DRD2
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	6CM4
Identificadores
Nomes alternativos	DRD2
IDs externos	OMIM: 126450 HomoloGene: 22561 GeneCards: DRD2
Targeted by Drug
	benzquinamide, LP-12, LP-211, LP-44, Ropinirol, (6S)-rotigotine, Vilazodona, 7-hydroxy-2-(di-N-propylamino)tetralin, bromocriptina, dopamina, pergolide, pramipexole, quinelorane, quinpirole, sumanirole, apomorfina, aripiprazol, Brexpiprazol, cabergolina, lisurida, piribedil, roxindole, Tergurida, amissulprida, blonanserin, (+)-butaclamol, clorpromazina, clozapina, domperidona, eticlopride, Flupentixol, Flufenazina, haloperidol, L-741,626, loxapina, mesoridazine, nafadotride, olanzapina, perospirone, perphenazine, pimozida, pipotiazine, prochlorperazine, promazina, quetiapina, raclopride, risperidona, sertindole, (RS)-sulpiride, levosulpiride, trifluoperazina, ziprasidona, zotepina[1]
Ontologia genética
Função molecular	• protein homodimerization activity; • potassium channel regulator activity; • dopamine neurotransmitter receptor activity, coupled via Gi/Go; • identical protein binding; • dopamine neurotransmitter receptor activity; • G protein-coupled receptor activity; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • signal transducer activity; • adrenergic receptor activity; • dopamine binding; • signaling receptor binding; • ionotropic glutamate receptor binding; • protein heterodimerization activity;
Componente celular	• GO:0016023 cytoplasmic vesicle; • sperm flagellum; • endocytic vesicle; • Acrossoma; • Espinha dendrítica; • synaptic vesicle membrane; • soma; • membrana plasmática; • dendrito; • ciliary membrane; • axon terminus; • integral component of membrane; • GO:0097483, GO:0097481 postsynaptic density; • membrane; • lateral plasma membrane; • axónio; • intracellular anatomical structure; • non-motile cilium; • integral component of plasma membrane; • dopaminergic synapse; • glutamatergic synapse; • GABA-ergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane;
Processo biológico	• negative regulation of cell population proliferation; • temperature homeostasis; • adenylate cyclase-inhibiting dopamine receptor signaling pathway; • adenohypophysis development; • circadian regulation of gene expression; • response to toxic substance; • regulation of dopamine secretion; • response to cocaine; • response to amphetamine; • sensory perception of smell; • locomotory behavior; • positive regulation of urine volume; • response to ethanol; • axonogenesis; • response to inactivity; • phospholipase C-activating dopamine receptor signaling pathway; • modulation of chemical synaptic transmission; • grooming behavior; • negative regulation of protein kinase B signaling; • associative learning; • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; • regulation of dopamine uptake involved in synaptic transmission; • regulation of synaptic transmission, GABAergic; • positive regulation of dopamine uptake involved in synaptic transmission; • GO:0072468 transdução de sinal; • Via de sinalização Wnt; • adult walking behavior; • branching morphogenesis of a nerve; • negative regulation of cytosolic calcium ion concentration; • negative regulation of innate immune response; • regulation of phosphoprotein phosphatase activity; • acid secretion; • feeding behavior; • positive regulation of G protein-coupled receptor signaling pathway; • response to axon injury; • striatum development; • synaptic transmission, dopaminergic; • nervous system process involved in regulation of systemic arterial blood pressure; • movimento peristáltico; • regulation of long-term neuronal synaptic plasticity; • activation of protein kinase activity; • positive regulation of growth hormone secretion; • regulation of sodium ion transport; • forebrain development; • response to light stimulus; • orbitofrontal cortex development; • prepulse inhibition; • response to morphine; • response to iron ion; • positive regulation of ERK1 and ERK2 cascade; • memória de longo prazo; • positive regulation of renal sodium excretion; • negative regulation of insulin secretion; • neuron-neuron synaptic transmission; • GO:0007243 intracellular signal transduction; • auditory behavior; • behavioral response to ethanol; • regulation of heart rate; • adenylate cyclase-activating adrenergic receptor signaling pathway; • positive regulation of cytokinesis; • regulation of potassium ion transport; • pigmentation; • cellular calcium ion homeostasis; • dopamine metabolic process; • response to nicotine; • regulation of MAPK cascade; • response to histamine; • negative regulation of synaptic transmission, glutamatergic; • response to hypoxia; • negative regulation of circadian sleep/wake cycle, sleep; • negative regulation of protein secretion; • Sinaptogênese; • regulation of locomotion involved in locomotory behavior; • dopamine receptor signaling pathway; • negative regulation of dopamine receptor signaling pathway; • startle response; • positive regulation of receptor internalization; • GO:0034613 protein localization; • arachidonic acid secretion; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • G protein-coupled receptor internalization; • positive regulation of multicellular organism growth; • positive regulation of long-term synaptic potentiation; • negative regulation of dopamine secretion; • adult behavior; • cerebral cortex GABAergic interneuron migration; • regulation of synapse structural plasticity; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • visual learning; • negative regulation of cell migration; • behavioral response to cocaine; • positive regulation of neuroblast proliferation; • negative regulation of blood pressure; • release of sequestered calcium ion into cytosol; • negative regulation of voltage-gated calcium channel activity; • G protein-coupled receptor signaling pathway; • negative regulation of adenylate cyclase activity; • potencial pós-sináptico excitatório; • GO:0033128 negative regulation of protein phosphorylation; • autofagia; • positive regulation of neurogenesis; • negative regulation of cell death; • drinking behavior; • adrenergic receptor signaling pathway; • regulation of neurotransmitter uptake; • postsynaptic modulation of chemical synaptic transmission; • regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	; ; ; ;
	Mais dados de referência de expressão
Ortólogos
	1813
	n/a
	ENSG00000149295
	n/a
	P14416
	n/a
	NM_016574; NM_000795
	n/a
	NP_000786; NP_057658; NP_000786.1
	n/a
	Wikidata
Ver/Editar Humano

O receptor D₂ de dopamina, também conhecido por D2R, é uma proteína que, em seres humanos, é codificada pelo gene DRD2.

Não só é o principal receptor da maioria dos medicamentos antipsicóticos, como foi através destes que foi identificado.[3]

Este gene codifica o subtipo D₂ dos receptores de dopamina. Este receptor acoplado à proteína G inibe a actividade da adenilato ciclase, sendo portanto associado à variante G_i_. Uma mutação missence neste gene causa distonia mioclónica; outras mutações têm sido associadas com a esquizofrenia.[4]

O splicing alternativo deste gene resulta em duas variantes de trancriptos que codificam diferentes isoformas. Uma terceira variante foi já descrita, mas não foi determinado se esta forma é normal ou devido a splicing alternativo.[5]

A variante longa (D2Lh) funciona como um tradicional receptor pós-sináptico. Já a versão curta (D2Sh) trata-se de um receptor pré-sináptico, que funciona como um autoreceptor, ou seja, pode aumentar ou reduzir a quantidade de dopamina libertada para o espaço extracelular, dependendo da quantidade presente.[6]

Referências

«Drogas que interagem fisicamente com dopamine receptor D2 ver/editar referências no wikidata»
«Human PubMed Reference:»
Madras, Bertha K. (2013). «History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopamine hypothesis of schizophrenia». Journal of the History of the Neurosciences. 22 (1): 62–78. ISSN 1744-5213. PMID 23323533. doi:10.1080/0964704X.2012.678199
Gene Overview of All Published Schizophrenia-Association Studies for DRD2 Arquivado em 21 de fevereiro de 2009, no Wayback Machine. - Schizophrenia Research Forum SZGene database.
«Entrez Gene: DRD2 dopamine receptor D2»
Beaulieu, Jean-Martin; Gainetdinov, Raul R. (Março 2011). «The physiology, signaling, and pharmacology of dopamine receptors». Pharmacological Reviews. 63 (1): 182–217. ISSN 1521-0081. PMID 21303898. doi:10.1124/pr.110.002642

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[1] «Drogas que interagem fisicamente com dopamine receptor D2 ver/editar referências no wikidata»

[2] «Human PubMed Reference:»

[3] Madras, Bertha K. (2013). «History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopamine hypothesis of schizophrenia». Journal of the History of the Neurosciences. 22 (1): 62–78. ISSN 1744-5213. PMID 23323533. doi:10.1080/0964704X.2012.678199

[SZGene-4] Gene Overview of All Published Schizophrenia-Association Studies for DRD2 Arquivado em 21 de fevereiro de 2009, no Wayback Machine. - Schizophrenia Research Forum SZGene database.

[entrez-5] «Entrez Gene: DRD2 dopamine receptor D2»

[6] Beaulieu, Jean-Martin; Gainetdinov, Raul R. (Março 2011). «The physiology, signaling, and pharmacology of dopamine receptors». Pharmacological Reviews. 63 (1): 182–217. ISSN 1521-0081. PMID 21303898. doi:10.1124/pr.110.002642

Receptor D2 de dopamina

Referências

Receptor D₂ de dopamina